The chemical synthesis of natural products provides an exciting platform from which to conduct fundamental research in chemistry and biology. Dr. Sarah E. Reisman’s laboratory has ongoing research programs targeting the chemical synthesis of several natural products. The densely packed arrays of heteroatoms and stereogenic centers that constitute these polycyclic targets challenge the limits of current technology and inspire the development of new synthetic strategies and tactics. This seminar describes their latest progress in both methodological and target-directed synthesis endeavors. Reisman is professor of chemistry and chemical engineering at California Institute of Technology. She is the recent recipient of several honors and awards, including ACS Women’s Chemist Committee Rising Star Award.