Our laboratory studies the genome organization of human viruses associated with cancer. Our long-term goal is to understand the structure-function relationships that couple 3D localization and transcriptional regulation. We have chosen to examine viruses as our systems of interest not only because of relevance to human disease, but also because the dramatic changes in gene expression during the viral life cycle provide manipulatable switches for dissecting regulatory mechanisms.
In addition to our efforts in discovery science, we are also working toward more translational goals by identifying small molecules that may serve as effective drugs in treating virus-associated malignancies.
- Molecular virology
- Gene regulation
- BIOL BC3320 Microbiology
- BIOL BC3321 Laboratory in Microbiology
- BIOL BC3591-3592 Guided Research & Seminar
- BIOL BC3593-3594 Senior Thesis Research & Seminar
- BIOL BC3597 Guided Research
- Class of '21 Award, Reed College
- Graduate Research Fellowship, National Science Foundation
- Certificate of Distinction in Teaching, Harvard University
- American Society for Microbiology
- International AIDS Society
I was interviewed by Carry The One Radio for a podcast on lifelong viral infections, Diplomatic Immunity in The Enemy of My Enemy.
Recent representative papers highlight our work in understanding viral gene regulation during cancer.
Moquin SA, Thomas S, Whalen S, Warburton A, Fernandez SG, McBride AA, Pollard KS, Miranda JL. The Epstein-Barr virus episome maneuvers between nuclear chromatin compartments during reactivation. Journal of Virology. 2018;92(3):e01413-17.
He A, Miranda JL. JQ1 reduces Epstein–Barr virus-associated lymphoproliferative disease in mice without sustained oncogene repression. Leukemia & Lymphoma. 2018;59(5):1248-51.
Keck KM, Moquin SA, He A, Fernandez SG, Somberg JJ, Liu SM, Martinez DM, Miranda JL. Bromodomain and extraterminal inhibitors block the Epstein-Barr virus lytic cycle at two distinct steps. Journal of Biological Chemistry. 2017;292(32):13284-95.