JJ Miranda, PhD
For more details about our research, please visit the lab website.
Our team studies the gene regulation of human viruses that cause cancer. We have chosen to examine viruses not only because of relevance to human disease, but also because dramatic changes in transcription during the life cycle provide manipulatable switches for dissecting regulatory mechanisms. In addition to our efforts with discovery science, we are also working toward more translational goals by identifying small molecules that may serve as effective drugs in treating virus-associated malignancies.
- Gene Regulation
- BIOL BC3320 Microbiology
- BIOL BC3321 Laboratory in Microbiology
- BIOL BC3591/2 Guided Research & Seminar
- BIOL BC3593/4 Senior Thesis Research & Seminar
- BIOL BC3597 Guided Research
- Class of '21 Award, Reed College
- Graduate Research Fellowship, National Science Foundation
- Certificate of Distinction in Teaching, Harvard University
- American Society for Microbiology
Recent papers highlight our work in understanding viral gene regulation during cancer.
Moquin SA, Thomas S, Whalen S, Warburton A, Fernandez SG, McBride AA, Pollard KS, Miranda JL. The Epstein-Barr virus episome maneuvers between nuclear chromatin compartments during reactivation. Journal of Virology. 2018;92(3):e01413-17.
He A, Miranda JL. JQ1 reduces Epstein–Barr virus-associated lymphoproliferative disease in mice without sustained oncogene repression. Leukemia & Lymphoma. 2018;59(5):1248-51.
Keck KM, Moquin SA, He A, Fernandez SG, Somberg JJ, Liu SM, Martinez DM, Miranda JL. Bromodomain and extraterminal inhibitors block the Epstein-Barr virus lytic cycle at two distinct steps. Journal of Biological Chemistry. 2017;292(32):13284-95.
A year after COVID-19 became a national emergency, a campus-run project to monitor coronavirus in wastewater is part of a multi-pronged effort to keep the community safe during the pandemic.
Despite the drastic changes to how research in Altschul has been conducted since last June, our laboratory technicians have been hard at work throughout the pandemic to help sustain productivity in our faculty labs alongside their PIs. Today, Olivia Anastasio, Lena Kogan (BC '19), Abby Ryckman (BC '18), and Nicole Rondeau (BC '18) join us to discuss what drives them as scientists and who they are outside of Altschul.