JJ Miranda, PhD
For more details about our research, please visit the lab website.
Our team studies the gene regulation of human viruses that cause cancer. We have chosen to examine viruses not only because of relevance to human disease, but also because dramatic changes in transcription during the life cycle provide manipulatable switches for dissecting regulatory mechanisms. In addition to our efforts with discovery science, we are also working toward more translational goals by identifying small molecules that may serve as effective drugs in treating virus-associated malignancies.
- Gene Regulation
- BIOL BC3320 Microbiology
- BIOL BC3321 Laboratory in Microbiology
- BIOL BC3591/2 Guided Research & Seminar
- BIOL BC3593/4 Senior Thesis Research & Seminar
- BIOL BC3597 Guided Research
- Class of '21 Award, Reed College
- Graduate Research Fellowship, National Science Foundation
- Certificate of Distinction in Teaching, Harvard University
- American Society for Microbiology
Recent papers highlight our work in understanding viral gene regulation during cancer.
Moquin SA, Thomas S, Whalen S, Warburton A, Fernandez SG, McBride AA, Pollard KS, Miranda JL. The Epstein-Barr virus episome maneuvers between nuclear chromatin compartments during reactivation. Journal of Virology. 2018;92(3):e01413-17.
He A, Miranda JL. JQ1 reduces Epstein–Barr virus-associated lymphoproliferative disease in mice without sustained oncogene repression. Leukemia & Lymphoma. 2018;59(5):1248-51.
Keck KM, Moquin SA, He A, Fernandez SG, Somberg JJ, Liu SM, Martinez DM, Miranda JL. Bromodomain and extraterminal inhibitors block the Epstein-Barr virus lytic cycle at two distinct steps. Journal of Biological Chemistry. 2017;292(32):13284-95.