Ann Whitney Olin Professor of Biology
Professor Glendinning joined the Barnard faculty in 1996. He studies the physiological mechanisms that control feeding in animals. Most of his projects focus on the contribution of taste to feeding, but he has recently begun to explore the effects of chemosensory feedback from the gut. Some of his current questions include:
- How does taste input interact with other feeding-related inputs (e.g., nutritive feedback from the gut) to stimulate or inhibit feeding?
- How does the peripheral taste system process the complex mixtures of chemicals that occur in food?
- How does experience (pre- or post-natal) with a food alter its orosensory properties?
- What is the relationship between sugar intake and weight gain?
- How does the taste system help animals feed in an adaptive manner—i.e., identify foods that are nutritious, toxic or medicinally beneficial?
He investigates these questions in mammals (mice and rats) and insects, using a combination of behavioral, electrophysiological, and molecular approaches.
Recent Publications (Barnard and Columbia students in Italics):
Glendinning JI (2016) Do low-calorie sweeteners increase weight gain in rodents? Physiology & Behavior 164: 509–513.
Glendinning JI, Stano S, Holter M, Azenkot T, Goldman O, Margolskee RF, Vasselli J, Sclafani A (2015) Sugar-induced cephalic-phase insulin release is mediated by a T1r2+T1r3-independent taste transduction pathway in mice. American Journal of Physiology 309: R552-R560
Glendinning JI, Elson AET, Kalik S, Sosa Y, Patterson CM, Myers MG Jr, Munger SD (2015) Taste responsiveness to sweeteners is resistant to elevations in plasma leptin. Chemical Senses 40(4): 223-231
Villalba JJ, Miller J, Ungar E, Landau SY, Glendinning JI (2014) Ruminant self-medication against gastrointestinal nematodes: evidence, mechanism, and origins. Parasite 21, 31
McCaughey S, Glendinning JI (2013) Experience with sugar modifies behavioral but not taste-evoked medullary responses to sweeteners in mice. Chemical Senses 38(9): 793–802
Afroz A, Howlett N, Shukla A, Ahmad F, Batista E, Bedard K, Payne S, Morton B, Mansfield JH, Glendinning JI (2013) Gustatory receptor neurons in Manduca sexta contain a TrpA1-dependent signaling pathway that integrates taste and temperature. Chemical Senses 38(7): 605-617
Zukerman S, Glendinning JI, Margolskee RF, Sclafani A (2013) Impact of T1r3 and Trpm5 on carbohydrate preference and acceptance in C57BL/6 mice. Chemical Senses 38(5): 421–437
Glendinning JI, Gillman J, Zamer H, Margolskee RF, Sclafani A (2012) The role of T1r3 and Trmp5 in carbohydrate-induced obesity in mice. Physiology & Behavior 107: 50–58
Howlett N, Dauber K, Shukla A, Morton B, Glendinning JI, Brent E, Gleason C, Islam F, Izquierdo D, Sanghavi S, Afroz A, Aslam A, Barbaro M, Blutstein R, Borkova M, Desire B, Elikis A, Fan Q, Hoffman K, Huang A, Keefe D, Lopatin S, Miller S, Patel P, Rizzini D, Robinson A, Rokins K, Turlik A, Mansfield JH (2012) Identification of chemosensory receptor genes in Manduca sexta and knockdown by RNA interference. BMC Genomics 13: 211
Cocco N, Glendinning JI (2012) Not all sugars are created equal: some mask noxious tastes better than others in an herbivorous insect. The Journal of Experimental Biology 215: 1412-1421.
Glendinning JI, Simons Y, Youngentob L, Youngentob S (2012) Fetal ethanol exposure attenuates aversive oral effects of TrpV1, but not TrpA1 agonists in rats. Experimental Biology and Medicine 237: 263-240
Ward R, Simpson E, Richards V, Deo G, Taylor K, Glendinning JI, Kandel E, Balsam P (2012) Dissociation of hedonic reaction to reward and incentive motivation in an animal model of the negative symptoms of schizophrenia. Neuropsychopharmacology 37(7): 1699-1707
Glendinning JI, Breinager L, Kyrillou E, Lacuna K, Rocha R, Sclafani A (2010) Differential effects of sucrose and fructose on dietary obesity in four mouse strains. Physiology & Behavior 101: 331-343
Glendinning JI, Beltran F, Benton L, Cheng S, Gieseke J, Gillman J, and Spain HN (2010) Taste does not determine daily intake of dilute sweet-tasting solutions in mice. American Journal of Physiology 299: R1333–R1341
Sclafani A, Glass DS, Margolskee RF and Glendinning JI (2010) Gut T1R3 sweet taste receptors do not mediate sucrose-conditioned flavor preferences in mice. American Journal of Physiology 299: R1643-R1650
Spector AC, Glendinning JI (2009) Linking peripheral taste processes to behavior. Current Opinion in Neurobiology 19: 370-377
Glendinning JI, Foley C, Loncar I, Rai M (2009) Induced preference for host plant chemicals in the tobacco hornworm: contribution of olfaction and taste. Journal of Comparative Physiology A 195: 591-601
Youngentob SL, Glendinning JI (2009) Fetal ethanol exposure increases ethanol intake by making it smell and taste better. Proceedings of the National Academy of Sciences USA 106(13): 5359-64
Zukerman S, Glendinning JI, Margolskee RF, Sclafani A (2009) T1R3 taste receptor is critical for sucrose but not Polycose taste. American Journal of Physiology 296: R866–R876
Laboratory in Animal Physiology
Statistics and Research Design
Click here to see some of his recent publications
In the News
A new study authored by John Glendinning, the Ann Whitney Olin Professor of Biology, along with Ana Paula Morales Allende (’15) and Joyce Tang (’17) suggests that fetal alcohol exposure (FAE) reduces the taste system’s responsiveness to the bitter flavor and burning sensation of many varieties of alcoholic beverages.